Beclin 1/BECN1抗体

产品货号：

Z11523

中文名称：

Beclin 1/BECN1抗体

英文名称：

Anti-Beclin 1/BECN1 Antibody

产品规格：

0.1mg

发货周期：

1～3天

产品价格：

询价

抗体名称	Anti-Beclin 1/BECN1 Antibody
指标别名	ATG6;Beclin 1;beclin 1;autophagy related;beclin1;BECN1;GT197;Protein GT197;VPS30;Beclin-1
克隆性	Polyclonal
检验物种	human,mouse,rat
应用范围	ELISA,WB,IHC,IF
基因名称	BECN1
抗体来源	Rabbit
抗体类型	IgG
免疫原	Anti-Beclin-1 antibody was raised against a peptide corresponding to 17 amino acids near the center of human Beclin-1.The immunogen is located between 40-90 amino acids of Beclin-1.
计算分子量	52kDa
成分	Beclin-1 Antibody is supplied in PBS containing 0.02% sodium azide.
纯化方式	Beclin-1 Antibody is affinity chromatography purified via peptide column.
浓度	1mg/mL
产品形态	溶液
保存条件	Beclin-1 antibody can be stored at 4℃ up to one year.Antibodies should not be exposed to prolonged high temperatures.
背景资料	Autophagy,the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells.Beclin-1,a coiled-coil Bcl-2-interacting protein homologous to the yeast autophagy gene apg6,is a mammalian autophagy gene that can inhibit tumorigenesis and is expressed at reduced levels in human breast carcinoma,suggesting that defects in autophagy proteins may contribute to the development or progression of tumors.Bcl-2 can bind to Beclin-1 and inhibit Beclin-1-dependent autophagy in yeast and mammalian cells,suggesting that Bcl-2 functions as an anti-autophagy protein as well as an anti-apoptotic protein,which helps maintain autophagy at levels that are more compatible with cell survival rather than cell death.
Uniprot ID	Q14457
基因名全称	Beclin 1,autophagy related
蛋白名全称	Beclin 1,autophagy related
推荐稀释比	WB:1μg/mL;IHC:2μg/mL;IF:20μg/mL.Antibody validated:Western Blot in human,mouse and rat samples;Immunohistochemistry in human,mouse,and rat samples;Immunofluorescence in human and mouse samples.All other applications and species not yet tested.

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